Cholesterol

Cholesterol

Synonyms 3β-Hydroxy-5-cholestene; 5-Cholesten-3β-ol; (3β)-cholest-5-en-3-ol

CAS Number: 57-88-5 Molecular Formula: C27H46O Molecular Weight: 386.664 g/mol

Beilstein Registry Number: 1915888 EC Number: 200-353-2 MDL Number: MFCD00003646

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SKU 02101382-CF
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Description

Product Description

Cholesterol

Application Notes

Cholesterol is a component used for the preparation and study of artificial model membranes. One example is a study of valinomycin induced changes in membrane potentials of red blood cell and phospholipid (phosphatidylcholine from egg yolk plus cholesterol) vesicle suspensions. Positively charged cyanine dyes were used that fluorimetrically respond to the change in potential. Cholesterol is suitable for use in liposome preparations. It is standard for clinical work.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Cell Signaling||Metabolic Pathways

Specifications
SKU 02101382-CF
Application Notes Cholesterol is a component used for the preparation and study of artificial model membranes. One example is a study of valinomycin induced changes in membrane potentials of red blood cell and phospholipid (phosphatidylcholine from egg yolk plus cholesterol) vesicle suspensions. Positively charged cyanine dyes were used that fluorimetrically respond to the change in potential. Cholesterol is suitable for use in liposome preparations. It is standard for clinical work.
Beilstein Registry Number 1915888
Biochemical Physiological Actions Major component of all biological membranes; ~25% of total brain lipid is cholesterol. It is an essential structural component of mammalian cell membranes and is required to establish proper membrane permeability and fluidity. In addition to its importance within cells, cholesterol also serves as a precursor for the biosynthesis of steroid hormones, bile acids, and vitamin D. Cholesterol is the principal sterol synthesized by animals; in vertebrates it is formed predominantly in the liver. Small quantities are synthesized in other cellular organisms (eukaryotes) such as plants and fungi. It is almost completely absent among prokaryotes (i.e., bacteria).
Boiling Point 360 °C
Certifications Standard for Clinical Work
Density 1.067 @ 20 deg C/4 deg C
EC Number 200-353-2
Format powder
Applications Cell Signaling||Metabolic Pathways
Loss on Drying ≤1.0%
Melting Point 148.5 °C
Molecular Formula C27H46O
Molecular Weight 386.664 g/mol
Optical Rotation -34° to -42°
Personal Protective Equipment Eyeshields, Gloves, Respirator filter
Physical Appearance White Powder
Product Families Description Cholesterol
Product Overview Cholesterol
Purity ≥99%
RTECS Number FZ8400000
Solubility <h5 class="minor-section-title">Water Solubility</h5>0.095 mg/L (at 30 °C)
Storage and Handling -20 °C.
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.