Dino

Prostaglandin E2

Prostaglandin E2

Synonyms 5Z,11α,13E,15S]-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid; Dinoprostone; PGE2

CAS Number: 363-24-6 Molecular Formula: C20H32O5 Molecular Weight: 352.471 g/mol

Beilstein Registry Number: 4709356 EC Number: 206-656-6 MDL Number: MFCD00077861

SKU 02195461-CF
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Description

Product Description

Prostaglandin E2

Application Notes

Prostaglandin E2 induces cervical ripening and parturition; mediates bradykinin-induced vasodilation.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Induces cervical ripening and parturition

Specifications
SKU 02195461-CF
Application Notes Prostaglandin E2 induces cervical ripening and parturition; mediates bradykinin-induced vasodilation.
Beilstein Registry Number 4709356
Biochemical Physiological Actions Most biologically active prostaglandin. PGE2 induces cervical ripening and parturition; mediates bradykinin-induced vasodilation; regulates adenylyl cyclase. Tumor cells that over-express cyclooxygenase 2 display increased invasiveness, angiogenesis, and resistance to apoptosis that may be due to the PGE2-induced expression of angiogenic factors and stabilization of the anti-apoptotic protein, survivin.The effect of PGE2 on the immune system is mixed. It inhibits T cell activation in vitro, suggesting it is an immunosuppressant. However, in vivo, it appears to effect expansion of the Th17 subset and differentiation of the Th1 subset of T helper cells, marking it as an immunoactivator.
EC Number 206-656-6
Format powder
Hazard Statements H302-H360
Applications Induces cervical ripening and parturition
Melting Point 67 °C
Molecular Formula C20H32O5
Molecular Weight 352.471 g/mol
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator, Gloves, respirator filter, respirator cartridges
Physical Appearance White Powder
Product Families Description Prostaglandin E2
Product Overview Prostaglandin E2
Purity ≥99%
RTECS Number UK8000000
Safety Symbol GHS07, GHS08
Solubility Water Solubility58.1 mg/L
Source Synthetic
Storage and Handling Store at -20 °C. Store Desiccated.
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.