Pyrazinamide

Pyrazinamide

Synonyms Pyrazinecarboxamide; Pyrazinoic acid amide

CAS Number: 98-96-4 Molecular Formula: C5H5N3O Molecular Weight: 123.115 g/mol

Beilstein Registry Number: 112306 EC Number: 202-717-6 MDL Number: MFCD00006132

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SKU 02195473-CF
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Description

Product Description

Pyrazinamide

Application Notes

Pyrazinamide is used therapeutically as an antitubercular agent. Pyrazinamide is used to form polymeric copper complexes, create pyrazine carboxamide scaffolds useful as FXs inhibitors, and as a component of mycobacteria identification kits. It is used to study liver toxicity prevention and mechanisms of resistance.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Antitubercular agent

Specifications
SKU 02195473-CF
Application Notes Pyrazinamide is used therapeutically as an antitubercular agent. Pyrazinamide is used to form polymeric copper complexes, create pyrazine carboxamide scaffolds useful as FXs inhibitors, and as a component of mycobacteria identification kits. It is used to study liver toxicity prevention and mechanisms of resistance.
Beilstein Registry Number 112306
Biochemical Physiological Actions The active moiety of pyrazinamide is pyrazinoic acid (POA). POA is thought to disrupt membrane energetics and inhibit membrane transport function at acid pH in Mycobacterium tuberculosis. Iron enhances the antituberculous activity of pyrazinamide. Pyrazinamide and its analogs have been shown to inhibit the activity of purified FAS I.
Boiling Point SUB (NTP, 1992)
EC Number 202-717-6
Format powder
Applications Antitubercular agent
Melting Point 376 to 379° F (NTP, 1992)
Molecular Formula C5H5N3O
Molecular Weight 123.115 g/mol
Personal Protective Equipment Eyeshields, Gloves, respirator filter
pH Aqueous solutions are neutral
Physical Appearance White Powder
Product Families Description Pyrazinamide
Product Overview Pyrazinamide
Purity ≥99%
RTECS Number UQ2275000
Solubility >18.5 [ug/mL]
Storage and Handling Store at Room Temperature (15-30 °C).
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.