Dino

Tobramycin

Tobramycin

Synonyms Nebramycin Factor 6; O-[3-Amino-3-deoxy-a-D-glucopyranosyl-(1?6)]-O-[2,6-diamino-2,3,6-trideoxy-a-D-ribohexopyranosyl-(1?4)]-2-deoxy-D-streptamine

CAS Number: 32986-56-4 Molecular Formula: C18H37N5O9 Molecular Weight: 467.52 g/mol

Beilstein Registry Number: 1357507 EC Number: 251-322-5 MDL Number: MFCD00077885

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SKU 02199697-CF
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Description

Product Description

Tobramycin

Application Notes

Tobramycin has been used:• to study the effect of tobramycin on bacteriophage infected biofilms• to study the effects of antibiotics on Pseudomonas aeruginosa strain• as a comparator antibiotic

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Specifications
SKU 02199697-CF
Application Notes Tobramycin has been used:• to study the effect of tobramycin on bacteriophage infected biofilms• to study the effects of antibiotics on Pseudomonas aeruginosa strain• as a comparator antibiotic
Beilstein Registry Number 1357507
Biochemical Physiological Actions Tobramycin is an aminoglycoside. Mode of Action: Binds to 70S ribosomal subunit; inhibits translocation; elicits miscoding. Spectrum of Activity: Gram negative bacteria. Not effective against Enterococci.Tobramycin binds irreversibly to one of two aminoglycoside binding sites on the 30S ribosomal subunit, inhibiting bacterial protein synthesis. Tobramycin may also destabilize bacterial membranes by binding to 16S rRNA (ribosomal RNA). It inhibits translocation and elicits miscoding.Tobramycin is used to treat Pseudomonas aeruginosa lung infections and is used in combination with other antibiotics to treat urinary tract infections, gynecologic infections, peritonitis, endocarditis, pneumonia, sepsis, respiratory infections, osteomyelitis, and other soft-tissue infections. It is a potential therapy for sinus infections.
EC Number 251-322-5
Format powder
Grade USP
Hazard Statements H315+H319+H317+H335
Heavy Metals ≤0.003%
Molecular Formula C18H37N5O9
Molecular Weight 467.52 g/mol
pH Basic substance
Physical Appearance Off-white Powder
Potency ≥900 µg/mg
Product Families Description Tobramycin
Product Overview Tobramycin
Residue on Ignition ≤1.0%
Safety Symbol GHS08, GHS07
Solubility Water Solubility1000 mg/ml
Storage and Handling +4°C
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Vapor Pressure 2.37X10-21 mm Hg at 25 deg C (est)