BOVINE FIBRINOGEN 90% CLOTTABLE

BOVINE FIBRINOGEN 90% CLOTTABLE

Synonyms Factor I; Fibrinogen from New Zealand sourced bovine plasma

CAS Number: 9001-32-5 Molecular Weight: α-chain mol wt 63.5 kDa, β-chain mol wt 56 kDa, γ chain mol wt 47 kDa (about 4% carbohydrate content), soluble dimer mol wt 340 kDa (Lit.)

EC Number: 232-598-6 MDL Number: MFCD00163624

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SKU 0882022-CF
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Specifications
SKU 0882022-CF
Application Notes Bovine fibrinogen has been used in studies of haemostatic therapy in surgical and massive trauma patients. These studies have shown that fibrinogen may prove to be more superior in stopping blood loss when compared to using fresh frozen plasma (FFP). It can be used for preparation of fibrin plates for analysis of fibrinolytic enzymes, a substrate for clotting assays, and study of fibrinogen degradation products.
Biochemical Physiological Actions Fibrinogen is an acute phase protein that is part of the coagulation cascade of proteins. The end result of the cascade is the production of thrombin that converts fibrinogen to fibrin. Thrombin rapidly proteolyzes fibrinogen, releasing fibrinopeptide A. The loss of this small peptide is not sufficient to make the resulting fibrin molecule insoluble, but it tends to form complexes with adjacent fibrin and fibrinogen molecules. Thrombin then cleaves a second peptide, fibrinopeptide B, from fibrin and the fibrin monomers formed then polymerize spontaneously to form an insoluble gel. The polymerized fibrin is held together by noncovalent and electrostatic forces and stabilized by the transamidating enzyme, factor XIIIa, that is produced by the action of thrombin on factor XIII. The insoluble fibrin aggregates (clots) and aggregated platelets then block the damaged blood vessel and prevent further bleeding. The amount of fibrinogen in the plasma can serve as a nonspecific indicator of whether or not an inflammatory process is present in the body. Fibrinogen from any mammalian source will be cleaved by thrombin from any mammalian source.
Concentration Protein: 70% w/w, balance excipients
EC Number 232-598-6
Gene ID Cow- FGA(522039), FGB(510522), FGG(280792)
Applications Substrate for clotting assays
Moisture Content 0.022
Molecular Weight α-chain mol wt 63.5 kDa, β-chain mol wt 56 kDa, γ chain mol wt 47 kDa (about 4% carbohydrate content), soluble dimer mol wt 340 kDa (Lit.)
Pack Size No
Personal Protective Equipment Eyeshields, Gloves, respirator filter
pH 6.4 (1% w/v in saline )
Physical Appearance White Powder
Presentation White powder
Protein or Enzyme Type Plasma & Blood Proteins
Recommended Replacement For 882021
Solubility Soluble in saline. Clear to slightly, hazy solution.
Source New Zealand
Storage and Handling Store product at <-10 °C.
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.